Two-component vasopressor therapy for septic shock

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Vasopressor support in septic shock.

When fluid administration fails to restore an adequate arterial pressure and organ perfusion in patients with septic shock, therapy with vasopressor agents should be initiated. The ultimate goals of such therapy in patients with shock are to restore effective tissue perfusion and to normalize cellular metabolism. Although arterial pressure is the end point of vasopressor therapy, and the restor...

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Relative Bradycardia in Patients With Septic Shock Requiring Vasopressor Therapy.

OBJECTIVES Tachycardia is common in septic shock, but many patients with septic shock are relatively bradycardic. The prevalence, determinants, and implications of relative bradycardia (heart rate, < 80 beats/min) in septic shock are unknown. To determine mortality associated with patients who are relatively bradycardic while in septic shock. DESIGN Retrospective study of patients admitted fo...

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Intensity of Vasopressor Therapy for Septic Shock and the Risk of In-Hospital Death.

CONTEXT Given the high mortality of 30%-60% associated with septic shock, distinguishing which patients do or do not have a reasonable chance of surviving with aggressive treatment could help clinicians and families make informed decisions. OBJECTIVES To determine if intensity of vasopressor therapy accurately predicts in-hospital death. METHODS This observational cohort study analyzed in-h...

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Choice of vasopressor in septic shock: does it matter?

Septic shock is a medical emergency that is associated with mortality rates of 40-70%. Prompt recognition and institution of effective therapy is required for optimal outcome. When the shock state persists after adequate fluid resuscitation, vasopressor therapy is required to improve and maintain adequate tissue/organ perfusion in an attempt to improve survival and prevent the development of mu...

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Skin Necrosis after High Dose Vasopressor Infusion in Septic Shock

Survival sepsis campaign recommends that vasopressor therapy is required to maintain mean arterial pressure (MAP) ≥ 65 mmHg. However, the absolute maximum dose of vasopressor is difficult to determine. Herein, we report 2 cases of severe skin necrosis after high dose vasopressor infusion to maintain the recommended MAP in septic shock. In our first case, norepinephrine 1.0-2.0 μg/kg/min and vas...

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ژورنال

عنوان ژورنال: Messenger of ANESTHESIOLOGY AND RESUSCITATION

سال: 2021

ISSN: 2541-8653,2078-5658

DOI: 10.21292/2078-5658-2021-18-1-57-64